MassQC Help > Troubleshooting > Ion Source > Long Term Degradation          
Ion Source and Long Term Degradation

When the ion source begins to ionize less efficiently, a noticeable change in signal can be present. Although in the Dashboard we see an increased Precursor m/z, this alerts us to a bigger picture trend. The picture below shows an increase in Precursor m/z, but if you click the Control Charts tab and dig deeper, you see the trend.

Increase in Precursor m/z

In this case, we see long term signal degradation, correlating with decreasing Precursor m/z and an overall decrease in the number of Peptide Counts:

Long Term Signal Degradation

Often, MassQC will lead you to sift through the historical data in a way you may not otherwise expect. This can be a great deal of help when you notice problems that are of a more subtle nature.

Metrics discussed this section:

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